| Insert |
DNA: genomic Insert lengths(kb): 2.5 Gene product: DNA Segment, single copy [D10S5] Alleles: B2, B1, A2, C1, C2, A1 |
| Comments |
Restriction digests of the clone give the following sizes (kb): HindIII--2.6, 2.4; EcoRI/HindIII--2.6, 2.4; BamHI--5.0; SalI--5.0; PstI--5.0. A co-dominant segregation pattern in 5 families in which Multiple Endocrine Neoplasia Type 2A is present. Linkage between D10S5 and disease locus detected with a maximum LOD score of 3.58 at a recombination frequency of 0.19. Enzyme(s) not detecting polymorphism: MspI, HindIII. |
| References |
White RL, et al. The CEPH consortium primary linkage map of human chromosome 10. Genomics 6: 393-412, 1990. PubMed: 1970325
Simpson NE, et al. Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage. Nature 328: 528-530, 1987. PubMed: 2886918
McDermid HE, et al. A polymorphic locus, D10S5, at 10q21.1. Nucleic Acids Res. 15: 5498, 1987. PubMed: 2885808
|
