| 產品名稱 |
Influenza A virus (H1N1) |
| 商品貨號 |
B191852 |
| Classification |
Orthomyxoviridae, Influenzavirus A |
| Agent |
Influenza A virus (H1N1) |
| Strain |
Monoclonal Anti-Influenza Virus H1 Hemagglutinin (HA), A/South Carolina/1/1918 (H1N1), Clone 5D3 (produced in vitro) |
| Applications |
Emerging infectious disease research Respiratory research Influenza Research |
| Biosafety Level |
1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Product Format |
frozen Each vial of VR-1668 contains approximately 100 µL of purified monoclonal antibody in PBS. |
| Storage Conditions |
?Store at -20°C or colder immediately upon arrival Repeated freeze-thaw cycles should be avoided |
| Comments |
Antibody class: IgG2aκ The B cell hybridoma was generated by the fusion of Sp2/0 BALB/c mouse myeloma cells with splenocytes from mice immunized by DNA vaccination with a plasmid encoding the HA of influenza virus, A/South Carolina/1/1918 (H1N1) and then boosted with whole inactivated virus. |
| Name of Depositor |
A Garcia-Sastre |
| Source |
Mouse monoclonal antibody prepared against the H1 hemagglutinin (HA) of influenza virus A/South Carolina/1/1918 (H1N1) was purified from clone 5D3 hybridoma supernatant by protein G affinity chromatography. |
| References |
Manicassamy B, et al. Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines. PLoS Pathog. 6: e1000745, 2010. PubMed: 20126449
Tumpey TM, et al. Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus. Proc. Natl. Acad. Sci. USA. 99: 13849-13854, 2002. PubMed: 12368467
Glaser L, et al. A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity. J. Virol. 79: 11533-11536, 2005. PubMed: 16103207
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