Restriction digests of the clone give the following sizes (kb): PstI--3.2, 2.3, 0.6; BamHI--6.5; EcoRI--5.6, 1.15; HindIII--3.9, 2.5; SmaI--6.5. Linkage is demonstrated between hypophosphatemic rickets (HYP) and DXS197 (theta = 0.193, LOD score = 2.68). Hybridizes to two bands, 2.6 and 1.5 kb, in PstI digests of human DNA. This probe was isolated from the lambdasHX library. |