The Cell Death Pathway BCL-2 Family Cell Line Panels 1 & 2 are useful for the study of cell apoptosis signaling pathways, BCL-2 family member molecular mechanisms, and mitochondrial dysfunction.
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
The Cell Death Pathway BCL-2 Family Cell Line Panel 1 is composed of five Jurkat leukemia cell lines that stably overexpress either wild-type BCL-2 or a mutant form of BCL-2. The BCL-2 mutations include phosphorylation site substitutions S70A, S87A, and a triple subsitution AAA (T69A, S70A, S87A). Mutations have been sequenced and validated by ATCC.
