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EGFR Genetic Alteration Cell Panel
EGFR Genetic Alteration Cell Panel
規格:
貨期:
編號:B162428
品牌:Mingzhoubio

標準菌株
定量菌液
DNA
RNA

規格:
凍干粉
斜面
甘油
平板


產品名稱
EGFR Genetic Alteration Cell Panel
商品貨號
B162428
Organism
Homo sapiens, human
Components
ATCC CRL-2868 HCC827
ATCC CRL-2871 HCC4006
ATCC CCL-231 SW48
ATCC CRL-5908 NCI-H1975
ATCC HTB-132 MDA-MB-468
ATCC HTB-19 BT-20
ATCC HTB-178 NCI-H596
ATCC HTB-177 NCI-H460
ATCC CRL-5928 NCI-H2170
ATCC HTB-20 BT-474
ATCC HTB-27 MDA-MB-361
Applications
This panel is useful for EGFR pathway research and for anti-cancer drug discovery.
Biosafety Level
1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Comments
EGFR/ERBB1/HER1 and ERBB2/EGFR2/HER2 are members of the ErbB super family of receptor tyrosine kinases. These receptors bind multiple EGF family-member ligands to initiate signaling cascades critical for an array of cellular processes, such as proliferation, differentiation, survival, metabolism, and migration. EGFR and ERBB2 are targets of an expanding class of anticancer therapies. The most common mutations associated with sensitivity to EGFR inhibitors include exon 19 deletions and the L858R point mutation.  Conversely, the EGFR T790M Mutation has been linked to drug resistance.  

The EGFR genetic alteration cell panel (ATCC TCP-1027) is composed of eleven human tumor cell lines from various common cancer types that carry hotspot mutations or gene copy number amplification within the EGFR or ERBB2 gene. The EGFR and ERBB2 status of each cell line has been sequenced and validated by ATCC. This panel is useful for EGFR pathway research and for anti-cancer drug discovery.

Product Format
frozen
Storage Conditions
LN vapor (less than -130°C) only
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