Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
The line was established from mononuclear cells taken from a fragile-X premutation female with 31 and 59 CGG-triplet repeats in the fragile-X gene, FMR1. This allele size is the smallest undergoing expansion to a full mutation (greater than 200 repeats) in one transmission. This expansion to a full mutation with greater than 200 repeats occurs only on transmission through females. Fragile X is a common cause of inherited mental retardation and is caused by an expansion of a CGG repeat within the gene.
