| Insert |
DNA: genomic Insert lengths(kb): 15.80000019073486 Tissue: liver Gene product: DNA Segment, single copy [D17S36] Alleles: A1, A2, A3, B1, B2 |
| Comments |
Restriction digests of the clone give the following sizes (kb): EcoRI--23.0, 12.0, 5.8, 4.6, 4.0, 1.4; BamHI--23.0, 14.0, 7.6, 6.0, 3.8; HindIII-->23.0, 12.0, 6.2, 3.5; BglII-->23.0, 8.4 (doublet), 4.6, 2.0; PvuI-->23.0, 16.0, 4.6, 2.6, 2.0. The MspI and BglII polymorphisms have a combined PIC value of 0.60 and a combined heterozygosity of 67%. Enzyme(s) not detecting polymorphism: EcoRI, HindIII, PstI, TaqI, BamHI, HincII, RsaI (panel of 5 individuals). |
| References |
Schumm JW, et al. Identification of more than 500 RFLPs by screening random genomic clones. Am. J. Hum. Genet. 42: 143-159, 1988. PubMed: 2892396
Donis-Keller H, et al. A genetic linkage map of the huma genome. Cell 51: 319-337, 1987. PubMed: 3664638
Stephens K, et al. Linkage studies with chromosome 17 DNA markers in 45 neurofibromatosis families. Genomics 1: 353-357, 1987. PubMed: 2896629
Upadhyaya M, et al. Chromosome 17 markers and von Recklinghausen neurofibromatosis: a genetic linkage study in the British population. Genomics 1: 358-360, 1987. PubMed: 2896630
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