Restriction digests of the clone give the following sizes (kb): EcoRI--3.1, 2.2; BamHI--5.0, 0.5; SalI--5.5; PstI--2.6; HindIII--5.5; PvuII--4.4, 0.4. This is linked to the F8C gene. Linkage has been demonstrated between X-linked recessive hydrocephalus (HSAS) and DXS15 (theta = 0.00, LOD score = 3.40). |